combinatorics GTO ranges Dive into the world of six-card PLO with Fernando "JNandezPoker" Habegger, exploring unique hand dynamics, strategic shifts from traditional Omaha formats, and critical preflop considerations that transform poker decision-making. Six-card PLO dramatically increases hand complexity, challenging traditional Omaha strategies with exponentially more combinations and nuanced preflop decision-making. Strategic Insights in Six-Card PLO: Massive increase in hand combinations (20 million possible hands) Triple-suited hands become strategically significant Pocket aces lose their traditional dominance Single-suited hands become much weaker Preflop frequencies radically change Flopping nuts no longer guarantees victory Increased importance of hand connectivity and backup draws